The Challenge of Accumulated Double-strand Breaks for Space Colonization

SAMUEL MCKEELIAM MCGUFFIN

2026.79.0244

DOI https://doi.org/10.59332/jbis-079-07-0244

Astronauts are exposed to far higher levels of radiation in space than on earth, which is compounded in deep space travel. Furthermore, human physiology underperforms, and the immune system is suppressed in microgravity. Research on astronauts in short and long duration missions has shown elevated levels of DNA repair breakdown as well as on model organisms studied in space. Solar radiation and galactic cosmic rays in particular pose an enormous threat due to high levels of double-strand breaks in the DNA which pose the highest risks of cancer, and potential fatality. In this paper we shall outline several courses of action, some potentially exciting possibilities, and how people could survive long term under the risk of accruing larger levels of double-strand breaks, drawing on protein study at the University of Reading.

Keywords: DNA repair, Bioastronautics, Space Medicine, Genetic Engineering, Radiation, Cancer, Space Weather, Cosmic Rays